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Test ID: HBIM Hepatitis B Core Antibody, IgM, Serum

Reporting Name

HBc IgM Ab, S

Useful For

Diagnosis of acute hepatitis B infection

 

Identifying acute hepatitis B virus (HBV) infection in the serologic window period when hepatitis B surface antigen (HBsAg) and antihepatitis B surface (anti-HBs) are negative

 

Differentiation between acute and chronic or past hepatitis B viral infections in the presence of positive anti-hepatitis B core

Specimen Type

Serum SST


Necessary Information


Date of draw is required.



Specimen Required


Patient Preparation: For 24 hours before specimen collection do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.

Collection Container/Tube: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Centrifuge blood collection tube per collection tube manufacturer's instructions.

2. Aliquot serum into plastic tube.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum SST Frozen (preferred) 28 days
  Refrigerated  7 days
  Ambient  24 hours

Reference Values

Negative 

 

See Viral Hepatitis Serologic Profiles in Special Instructions.

Day(s) and Time(s) Performed

Monday through Saturday; Varies

Test Classification

This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86705

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HBIM HBc IgM Ab, S 24113-3

 

Result ID Test Result Name Result LOINC Value
HBIM HBc IgM Ab, S 24113-3

Clinical Information

Hepatitis B virus (HBV) is a DNA virus that is endemic throughout the world. In the initial (acute) phase of infection, anti-hepatitis B core antibodies (anti-HBc) consist almost entirely of the IgM antibody class and appear shortly after the onset of symptoms. Anti-HBc IgM antibody can be detected in serum and is usually present for up to 6 months after acute HBV infection. Anti-HBc IgM may be the only serologic marker of a recent hepatitis B infection detectable following the disappearance of hepatitis B surface antigen (HBsAg) and prior to the appearance of hepatitis B surface antibody (anti-HBs) (ie, serologic window period).

 

See Viral Hepatitis Serologic Profiles in Special Instructions.

Interpretation

A positive result indicates recent acute hepatitis B infection.

 

A negative result suggests lack of recent exposure to the virus in preceding 6 months.

Clinical Reference

1. Bonino F. Piratvisuth T, Brunetto MR, et al: Diagnostic markers of chronic hepatitis B infection and disease. Antiviral Therapy. 2010;15(Suppl. 3):35-44

2. Badur S, Akgun A: Diagnosis of hepatitis B infections and monitoring of treatment. J Clin Virol. 2001;21:229-237

3. Servoss JC, Friedman LS: Serologic and molecular diagnosis of hepatitis B virus. Clin Liver Dis. 2004;8:267-281

4. LeFebre ML: U.S. Preventive Services Task Force: Screening for hepatitis B virus infection in nonpregnant adolescents and adults: U.S. Preventive Services Task Force recommendation statement.  Ann Intern Med. 2014;161:58-66. doi: 10.7326/M14-1018

5. Jackson K, Locarnini S, Gish R: Diagnostics of hepatitis B virus: Standard of care and investigational. Clin Liver Dis. 2018;12(1):5-11. doi: 10.1002/cld.729

6. Coffin CS, Zhou K, Terrault NA: New and old biomarkers for diagnosis and management of chronic hepatitis B virus infection. Gastroenterol. 2019;156:355-368. doi: 10.1053/j.gastro.2018.11.037

7. WHO Guidleines Developent Group: World Health Organization: Guidelines on hepatitis B and C testing. World Health Organization; 2017. Accessed September 29, 2020. Available at: www.who.int/hepatitis/publications/guidelines-hepatitis-c-b-testing/en/

8. Centers for Disease Control and Prevention. Testing and public health management of persons with chronic hepatitis B virus infection. Accessed April 8, 2020. Available at: www.cdc.gov/hepatitis/hbv/testingchronic.htm

Analytic Time

1 day

Method Name

Chemiluminescence Immunoassay

Forms

If not ordering electronically, complete, print, and send a Gastroenterology and Hepatology Client Test Request (T728) with the specimen.

Testing Algorithm

See HBV Infection-Diagnostic Approach and Management Algorithm in Special Instructions.

Mayo Clinic Laboratories | Gastroenterology Catalog Additional Information:

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